Young Investigator Award Lecture of the Aps Water and Electrolyte Homeostasis
نویسنده
چکیده
Sasser JM. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 305: R559–R565, 2013. First published July 24, 2013; doi:10.1152/ajpregu.00528.2012.— Emerging evidence supports a potential therapeutic role of relaxin in fibrotic diseases, including chronic kidney disease. Relaxin is a pleiotropic hormone, best characterized for its role in the reproductive system; however, recent studies have demonstrated a role of relaxin in the cardiorenal system. Both relaxin and its receptor, RXFP1, are expressed in the kidney, and relaxin has been shown to play a role in renal vasodilation, in sodium excretion, and as an antifibrotic agent. Together, these findings suggest that the kidney is a target organ of relaxin. Therefore, the purpose of this review is to describe the functional and structural impacts of relaxin treatment on the kidney and to discuss evidence that relaxin prevents disease progression in several experimental models of kidney disease. In addition, this review will present potential mechanisms that are involved in the therapeutic actions of relaxin.
منابع مشابه
Water and Electrolyte Homeostasis Section Young Investigator Award Lecture. The Pathophysiology of Hypertension in Systemic Lupus Erythematosus
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متن کاملYoung Investigator Award Lecture of the Aps Water and Electrolyte
Sasser JM. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 305: R559–R565, 2013. First published July 24, 2013; doi:10.1152/ajpregu.00528.2012.— Emerging evidence supports a potential therapeutic role of relaxin in fibrotic diseases, including chronic kidney disease. Relaxin is a pleiotropic hormone, ...
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AS INITIATED BY MY PREDECESSOR, Dr. Amira Klip, we will, on occasion, highlight original research and review articles authored by recipients of awards offered by the American Physiological Society (APS), in particular, the Endocrinology & Metabolism Section of the APS. While this journal is not a forum for all APS activities or meant to be a repository for research performed by Society members,...
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4 5 L. Gabriel Navar, Ph.D. 6 7 Department of Physiology, Tulane Hypertension and Renal Center of Excellence, 8 Tulane University School of Medicine, New Orleans, LA 9 10 11 12 Short Running Title: 2016 Young Investigator Award-APS Renal Section 13 14 15 16 Corresponding Author: 17 L. Gabriel Navar, Ph.D. 18 Department of Physiology, 8639 19 Tulane University Health Sciences Center 2
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